Article
Development of zidovudine resistance mutations in patients receiving prolonged didanosine monotherapy.
The Journal of infectious diseases - 1 Dec 1995
Demeter L M, Nawaz T, Morse G, Dolin R, Dexter A, Gerondelis P, Reichman R C
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) isolates from 2 patients who received didanosine (ddI) monotherapy for > 2 years were analyzed for reverse transcriptase (RT) mutations by sequencing of proviral DNA from peripheral blood mononuclear cell cultures. One patient was otherwise antiretrovir...
Topics
- Acquired Immunodeficiency Syndrome
- Adult
- Antiviral Agents
- Base Sequence
- Didanosine
- Drug Resistance
- Female
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Male
- Molecular Sequence Data
- Mutation
- RNA-Directed DNA Polymerase
- Zidovudine