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Mutations in the 3A genomic region of two cytopathic strains of hepatitis A virus isolated in Italy.

Virus research - 1 May 1993

Morace G, Pisani G, Beneduce F, Divizia M, Panà A

Abstract excerpt

Two strains of hepatitis A virus (HAV) were isolated in cell culture and found to induce a cytopathic effect at early passages. The nucleotide sequences of the 5' non-translated region (5'NTR) and of genes 2B, 2C, 3A and 3B were determined for these strains and found to contain mutations similar to those detected in cell-culture adapted variants of HAV strain HM175. In addition, gene 3A shows a deletion of three...

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PMID: 8391192
DOI: 10.1016/0168-1702(93)90135-a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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