Alterations in the sequence of the gene 4 from a human rotavirus after multiple passages in HepG2 liver cells.

doi:10.1007/BF01319006

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Article

Alterations in the sequence of the gene 4 from a human rotavirus after multiple passages in HepG2 liver cells.

Archives of virology - 1 Jan 1993

Kitamoto N, Mattion N M, Estes M K

Abstract excerpt

The human Wa strain of rotaviruses, initially unable to grow in liver cells, was adapted by multiple passages to grow in HepG2 cells. The genome segment 4 of both the parental and passaged strains was cloned and sequenced. Five amino acid differences (residues 38, 120, 421, 525, and 618) were fou...

Topics

Amino Acid Sequence
Base Sequence
Carcinoma, Hepatocellular
DNA, Viral
Genes, Viral
Genetic Variation
Humans
Liver Neoplasms
Molecular Sequence Data
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Rotavirus
Sequence Homology, Amino Acid
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8389116
DOI: 10.1007/BF01319006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8389116-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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