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Article

Alterations in the sequence of the gene 4 from a human rotavirus after multiple passages in HepG2 liver cells.

Archives of virology - 1 Jan 1993

Kitamoto N, Mattion N M, Estes M K

Abstract excerpt

The human Wa strain of rotaviruses, initially unable to grow in liver cells, was adapted by multiple passages to grow in HepG2 cells. The genome segment 4 of both the parental and passaged strains was cloned and sequenced. Five amino acid differences (residues 38, 120, 421, 525, and 618) were found in the HepG2-passaged variant compared to the parental Wa strain. Our results support the hypothesis that viral...

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PMID: 8389116
DOI: 10.1007/BF01319006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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