Article
H-ras codon 12 mutation in cervical dysplasia.
Gynecologic oncology - 1 May 1993
Van Le L, Stoerker J, Rinehart C A, Fowler W C
Abstract excerpt
A mutation in codon 12 of the H-ras oncogene has been implicated in the pathogenesis of cervical cancer. To determine if mutational activation of H-ras is an early event in carcinogenesis, we looked for the presence of codon 12 H-ras mutation in precancerous cervical dysplasia. We analyzed cervical DNA from 63 normal patients and 72 patients with biopsy-proven cervical dysplasia [CIN I (48), CIN II (9), CIN III...
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