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Article

The constitution of a progesterone response element.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 1993

Lieberman B A, Bona B J, Edwards D P, Nordeen S K

Abstract excerpt

Progesterone receptors (PRs) recognize and bind to DNA in a sequence-specific manner. To define the sequence-specific determinants of PR binding to DNA, we employed a detailed series of target elements and analyzed both PR binding in vitro and PR-mediated activation of a reporter gene in vivo. These elements represent point substitution or insertion mutants of a progesterone response element derived from the...

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PMID: 8388996
DOI: 10.1210/mend.7.4.8388996

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