Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.

1 Dec 1994

Abstract excerpt

The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B). In most cell contexts, hPR-B functions as a transcriptional activator of progesterone-responsive genes, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors. We have created mutations within the carboxyl terminus of hPR which differentially effect the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to Hormonal Regulation and Hypertension
Share to Steroid Chemistry and Biochemistry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7969170
DOI: 10.1128/mcb.14.12.8356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.PMID 7969170Read ↗

The A and B Isoforms of the Human Progesterone Receptor Operate through Distinct Signaling Pathways within Target CellsSemantic proximity Read ↗

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.Semantic proximity Read ↗

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B functionSemantic proximity Read ↗

Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer CellsSemantic proximity Read ↗

Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors.Semantic proximity Read ↗

The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor BindingSemantic proximity Read ↗

Progesterone-Independent Effects of Human Progesterone Receptors (PRs) in Estrogen Receptor-Positive Breast Cancer: PR Isoform-Specific Gene Regulation and Tumor BiologySemantic proximity Read ↗

Roles of Progesterone Receptor A and B Isoforms During Human Endometrial DecidualizationSemantic proximity Read ↗

Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms.Semantic proximity Read ↗

Progesterone Receptors (PR)-B and -A Regulate Transcription by Different Mechanisms: AF-3 Exerts Regulatory Control over Coactivator Binding to PR-BSemantic proximity Read ↗

Progesterone action in breast, uterine, and ovarian cancersSemantic proximity Read ↗

Molecular determinants of context-dependent progesterone receptor action in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.