Article

The A and B Isoforms of the Human Progesterone Receptor Operate through Distinct Signaling Pathways within Target Cells

1994-12-01

Abstract excerpt

The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B). In most cell contexts, hPR-B functions as a transcriptional activator of progesterone-responsive genes, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors. We have created mutations within the carboxyl terminus of hPR which differentially effect the tr...

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Identifiers and source

Literature Corpus work: 136d02e0-9510-53a2-b619-daf99df10f80
DOI: 10.1128/mcb.14.12.8356-8364.1994

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