Article
Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis.
Journal of virology - 1 Jun 1993
Tyler K L, Mann M A, Fields B N, Virgin H W
Abstract excerpt
We used a recently isolated and characterized panel of monoclonal antibodies (MAbs) specific for cross-reactive determinants on reovirus outer capsid proteins to define mechanisms of antibody-mediated protection in vivo. We studied the capacities of MAbs to protect against lethal infection with reoviruses which differ in site of primary replication, route of spread, and central nervous system tropism. We found...
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