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A cross-reactive antibody protects against Ross River virus musculoskeletal disease despite rapid neutralization escape in mice

6 Aug 2020

Abstract excerpt

Arthritogenic alphaviruses cause debilitating musculoskeletal disease and historically have circulated in distinct regions. With the global spread of chikungunya virus (CHIKV), there now is more geographic overlap, which could result in heterologous immunity affecting natural infection or vaccination. Here, we evaluated the capacity of a cross-reactive anti-CHIKV monoclonal antibody (CHK-265) to protect against...

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PMID: 32760128
DOI: 10.1371/journal.ppat.1008743

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