Article
Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jul 1995
Dohlman H G, Apaniesk D, Chen Y, Song J, Nusskern D
Abstract excerpt
Genetic analysis of cell-cell signaling in Saccharomyces cerevisiae has led to the identification of a novel factor, known as Sst2p, that promotes recovery after pheromone-induced growth arrest (R. K. Chan and C. A. Otte, Mol. Cell. Biol. 2:11-20, 1982). Loss-of-function mutations lead to increased pheromone sensitivity, but this phenotype is partially suppressed by overexpression of the G protein alpha subunit...
Topics
- Cell Division
- Fungal Proteins
- GTP-Binding Protein alpha Subunits
- GTP-Binding Protein alpha Subunits, Gq-G11
- GTP-Binding Proteins
- GTPase-Activating Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Heterotrimeric GTP-Binding Proteins