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Article

Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jul 1995

Dohlman H G, Apaniesk D, Chen Y, Song J, Nusskern D

Abstract excerpt

Genetic analysis of cell-cell signaling in Saccharomyces cerevisiae has led to the identification of a novel factor, known as Sst2p, that promotes recovery after pheromone-induced growth arrest (R. K. Chan and C. A. Otte, Mol. Cell. Biol. 2:11-20, 1982). Loss-of-function mutations lead to increased pheromone sensitivity, but this phenotype is partially suppressed by overexpression of the G protein alpha subunit...

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Identifiers

PMID: 7791771
DOI: 10.1128/MCB.15.7.3635
PMCID: PMC230601

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