Article
Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival.
The EMBO journal - 1 Aug 1996
Strasser A, Elefanty A G, Harris A W, Cory S
Abstract excerpt
Mice expressing both a bcl-2 and a myc transgene within the B lymphoid cell compartment invariably develop novel immature haemopoietic tumours. The likely cell of origin of these tumours was identified by a common pattern of cell surface marker expression on a subset of cells comprising approxima...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Blotting, Northern
- Cell Differentiation
- Cell Survival
- DNA Primers
- Gene Expression Regulation, Leukemic
- Genes, myc
- Hematopoietic Stem Cells
- Lymphoma, B-Cell
- Macrophages
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Molecular Sequence Data
- Phenotype
- Proto-Oncogene Proteins