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Article

Potential Role for p53 in the Permissive Life Cycle of Human Cytomegalovirus

15 Aug 2006

Abstract excerpt

Infection of primary fibroblasts with human cytomegalovirus (HCMV) causes a rapid stabilization of the cellular protein p53. p53 is a major effector of the cellular damage response, and activation of this transcription factor can lead either to cell cycle arrest or to apoptosis. Viruses employ many tactics to avoid p53-mediated effects. One method HCMV uses to counteract p53 is sequestration into its viral...

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PMID: 16912290
DOI: 10.1128/jvi.00505-06

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