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Article

Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.

Biochemical and biophysical research communications - 22 Nov 1995

Weiss E R, Hao Y, Dickerson C D, Osawa S, Shi W, Zhang L, Wong F

Abstract excerpt

Transgenic mice expressing the rhodopsin mutant Pro347Ser (Serine 6) display retinal degeneration through apoptosis that is characteristic of the disease retinitis pigmentosa. By 5 weeks after birth, these mice have lost approximately 35% of their photoreceptor cells. Retinas from these mice showed higher levels of cAMP compared to the levels in retinas of normal mice. Our studies provide evidence that elevated...

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Source

Identifiers

PMID: 7488190
DOI: 10.1006/bbrc.1995.2686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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