Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.

doi:10.1006/bbrc.1995.2686

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Article

Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.

Biochemical and biophysical research communications - 22 Nov 1995

Weiss E R, Hao Y, Dickerson C D, Osawa S, Shi W, Zhang L, Wong F

Abstract excerpt

Transgenic mice expressing the rhodopsin mutant Pro347Ser (Serine 6) display retinal degeneration through apoptosis that is characteristic of the disease retinitis pigmentosa. By 5 weeks after birth, these mice have lost approximately 35% of their photoreceptor cells. Retinas from these mice show...

Topics

Animals
Apoptosis
Cyclic AMP
Guanosine 5'-O-(3-Thiotriphosphate)
Mice
Mice, Transgenic
Mutation
Photoreceptor Cells
Retina
Retinal Degeneration
Retinitis Pigmentosa
Rhodopsin
Serine
Signal Transduction

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