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Article

Generation of a Transgenic Rabbit Model of Retinal Degeneration

25 Feb 2009

Abstract excerpt

PURPOSE: To generate a transgenic (Tg) rabbit model of retinal degeneration and to characterize the pattern of degeneration by using histology and electrophysiology. METHODS: Rhodopsin Pro347Leu Tg rabbits were generated by BAC transgenesis. Tg rabbits were identified by Southern blot analysis, and the expression levels were measured by quantitative RT-PCR. Retinal histology was examined by light and electron...

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PMID: 19074802
DOI: 10.1167/iovs.08-2863

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