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Article

The pSC101 par locus alters protein-DNA interactions in vivo at the plasmid replication origin.

Journal of bacteriology - 1 Sept 1993

Ingmer H, Cohen S N

Abstract excerpt

We report here direct evidence that mutations in the par locus affect protein-DNA interactions in vivo at the replication origin of plasmid pSC101. Concomitant with par-mediated plasmid stabilization, two sites in the origin region show an altered methylation pattern as detected by in vivo footprinting with dimethyl sulfate. One site is located near an integration host factor-binding sequence adjacent to the...

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Identifiers

PMID: 8376350
DOI: 10.1128/jb.175.18.6046-6048.1993
PMCID: PMC206688

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The pSC101 par locus alters protein-DNA interactions in vivo at the plasmid replication origin.PMID 8376350Read ↗

Isolation and characterization of plasmid mutations that enable partitioning of pSC101 replicons lacking the partition (par) locus.Semantic proximity Read ↗

The par region of pSC101 affects plasmid copy number as well as stability.Semantic proximity Read ↗

Gyrase-dependent stabilization of pSC101 plasmid inheritance by transcriptionally active promoters.Semantic proximity Read ↗

Role of DNA superhelicity in partitioning of the pSC101 plasmid.Semantic proximity Read ↗

Transcriptional profiling of ParA and ParB mutants in actively dividing cells of an opportunistic human pathogen Pseudomonas aeruginosa.Semantic proximity Read ↗

Transcriptional interference by a complex formed at the centromere-like partition site of plasmid P1.Semantic proximity Read ↗

Silencing of genes flanking the P1 plasmid centromere.Semantic proximity Read ↗

Replication origin mutations affecting binding of pSC101 plasmid-encoded Rep initiator protein.Semantic proximity Read ↗

A single parS sequence from the cluster of four sites closest to oriC is necessary and sufficient for proper chromosome segregation in Pseudomonas aeruginosa.Semantic proximity Read ↗

Boundaries of the pSC101 minimal replicon are conditional.Semantic proximity Read ↗

Probing the N-terminus of ParB using cysteine-scanning mutagenesis and thiol modification.Semantic proximity Read ↗

Novel alleles of the Escherichia coli dnaA gene are defective in replication of pSC101 but not of oriC.Semantic proximity Read ↗

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