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Article

An endogenous suppressor of hairy-wing insulator separates regulatory domains in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Parnell Timothy J, Viering Michaela M, Skjesol Astrid, Helou Cecilia, Kuhn Emily J, Geyer Pamela K

Abstract excerpt

Insulators define independent domains of gene function throughout the genome. The Drosophila gypsy insulator was isolated from the gypsy retrotransposon as a region that contains a cluster of binding sites for the Suppressor of Hairy-wing [Su(Hw)] protein. To study the effects of the gypsy insulator on gene expression within a single genomic domain, targeted gene replacement was used to exchange the endogenous...

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Identifiers

PMID: 14597701
DOI: 10.1073/pnas.2333111100
PMCID: PMC263832

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Source receipt: pubmed, retrieved 7 Sept 2026.

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An endogenous suppressor of hairy-wing insulator separates regulatory domains in Drosophila.PMID 14597701Read ↗

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