Article
Genotoxic and mutagenic properties of Ni and NiO nanoparticles investigated by comet assay, γ-H2AX staining, Hprt mutation assay and ToxTracker reporter cell lines.
Environmental and molecular mutagenesis - 1 Apr 2018
Åkerlund Emma, Cappellini Francesca, Di Bucchianico Sebastiano, Islam Shafiqul, Skoglund Sara, Derr Remco, Odnevall Wallinder Inger, Hendriks Giel, Karlsson Hanna L
Abstract excerpt
Nickel (Ni) compounds are classified as carcinogenic to humans but the underlying mechanisms are still poorly understood. Furthermore, effects related to nanoparticles (NPs) of Ni have not been fully elucidated. The aim of this study was to investigate genotoxicity and mutagenicity of Ni and NiO NPs and compare the effect to soluble Ni from NiCl2 . We employed different models; i.e., exposure of (1) human...
Topics
- Animals
- Biological Assay
- Bronchi
- Cell Survival
- Cells, Cultured
- Comet Assay
- DNA Damage
- Embryonic Stem Cells
- Epithelial Cells
- Genes, Reporter
- Green Fluorescent Proteins
- High-Throughput Screening Assays