Article
Mercury-induced renal autoimmunity: changes in RT6+ T-lymphocytes of susceptible and resistant rats.
Environmental health perspectives - 1 Jun 1993
Kosuda L L, Greiner D L, Bigazzi P E
Abstract excerpt
The repeated administration of mercury to rats of the Brown Norway (BN) inbred strain results in a self-limiting production of autoantibodies to renal antigens (e.g., laminin) and autoimmune glomerulonephritis. In contrast, rats of the Lewis (LEW) strain do not develop renal autoimmunity after mercury treatment. Suppressor T-cells and/or the idiotype-anti-idiotype network have been implicated in the control of...
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