Article
Evidence of positive selection acting at the human dopamine receptor D4 gene locus.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2002
Ding Yuan-Chun, Chi Han-Chang, Grady Deborah L, Morishima Atsuyuki, Kidd Judith R, Kidd Kenneth K, Flodman Pamela, Spence M Anne, Schuck Sabrina, Swanson James M, Zhang Ya-Ping, Moyzis Robert K
Abstract excerpt
Associations have been reported of the seven-repeat (7R) allele of the human dopamine receptor D4 (DRD4) gene with both attention-deficit/hyperactivity disorder and the personality trait of novelty seeking. This polymorphism occurs in a 48-bp tandem repeat in the coding region of DRD4, with the most common allele containing four repeats (4R) and rarer variants containing 2-11. Here we show by DNA...
Topics
- Alleles
- Base Sequence
- Evolution, Molecular
- Exons
- Genetics, Population
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Molecular Sequence Data