Article
The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.
American journal of human genetics - 1 May 2004
Wang E, Ding Y-C, Flodman P, Kidd J R, Kidd K K, Grady D L, Ryder O A, Spence M A, Swanson J M, Moyzis R K
Abstract excerpt
Associations of the seven-repeat (7R) allele of the human dopamine receptor D4 (DRD4) gene with both the personality trait of novelty seeking and attention deficit/hyperactivity disorder have been reported. Recently, on the basis of the unusual DNA sequence organization of the DRD4 7R 48-bp tandem repeat (VNTR), we proposed that the 7R allele originated as a rare mutational event that increased to high frequency...
Topics
- Alleles
- Evolution, Molecular
- Exons
- Genetic Heterogeneity
- Genetics, Population
- Haplotypes
- Humans
- Linkage Disequilibrium
- Minisatellite Repeats
- Models, Genetic
- Mutation
- Polymorphism, Genetic
- Promoter Regions, Genetic