Article
Early detection of 2-amino-1-methyl-6-phenylimidazo (4,5-b)pyridine(PhIP)-induced mutations within the Apc gene of rat colon.
Carcinogenesis - 1 Feb 2001
Burnouf D, Miturski R, Nagao M, Nakagama H, Nothisen M, Wagner J, Fuchs R P
Abstract excerpt
A large proportion of human cancers result from exposure of individuals to environmental or occupational carcinogens. The early detection of carcinogen-induced mutations is a prerequisite for the identification of individuals at risk for developing cancer. Short G-rich repetitive sequences have been previously identified as hot-spots for frameshift mutagenesis induced by a large variety of carcinogens belonging...
Topics
- Animals
- Base Pair Mismatch
- Carcinogens
- Colonic Neoplasms
- DNA Primers
- DNA, Neoplasm
- Electrophoresis, Agar Gel
- Gene Deletion
- Genes, APC
- Humans
- Imidazoles
- Male
- Mutation
- Polymerase Chain Reaction
- Rats
- Rats, Inbred F344
- Sensitivity and Specificity