Article
Absence of p53 mutations in rat colon tumors induced by 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, 2-amino-3-methylimidazo[4,5-f]quinoline, or 2-amino-1-methyl-6-phenylimidazo]4,5-b]pyridine.
Japanese journal of cancer research : Gann - 1 May 1994
Makino H, Ushijima T, Kakiuchi H, Onda M, Ito N, Sugimura T, Nagao M
Abstract excerpt
Colon tumors were induced in F344 rats by three heterocyclic amines (HCAs), 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and examined for p53 mutations. Seven carcinomas induced...
Topics
- Adenocarcinoma
- Adenoma
- Animals
- Base Sequence
- Carcinogens
- Colonic Neoplasms
- Genes, ras
- Imidazoles
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Quinolines
- Rats
- Rats, Inbred F344