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Article

Genetic Determinants of Analgesic Responsiveness: A Focus on CYP2D6 and COMT Polymorphisms in Chronic Pain.

The Clinical journal of pain - 1 May 2026

Bollinger Anna, Stäuble Céline K, Urdieux Isabelle O, Gianora Julia, Schüpbach Tanja, Seibert Isabell, Wiss Florine M, Jeiziner Chiara, Hersberger Kurt E, Allemann Samuel S, Meyer Zu Schwabedissen Henriette E

Abstract excerpt

OBJECTIVES: Interindividual variability in analgesic responsiveness often results in therapy failure (TF) or adverse drug reactions (ADR) and poses a major challenge in chronic pain management, as it is influenced by multiple factors. This exploratory study investigated whether pharmacogenetic (PGx) testing could identify drug-gene interactions (DGIs) explaining variability in drug response. In addition, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41521967
DOI: 10.1097/AJP.0000000000001358

Genes

COMT
TF
CYP2C19
CYP2C9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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