Article
Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineutrophil cytoplasmic antibodies) markers.
The Journal of clinical investigation - 1 Aug 1993
Yang H, Rotter J I, Toyoda H, Landers C, Tyran D, McElree C K, Targan S R
Abstract excerpt
Newly described distinct associations of HLA class II genes with ulcerative colitis (UC) (DR2) and Crohn's disease (CD) (DR1/DQ5) provide strong evidence for genetic heterogeneity of susceptibility between these two forms of inflammatory bowel disease. A familial distribution of antineutrophil cy...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Autoantibodies
- Biomarkers
- Colitis, Ulcerative
- DNA
- Enzyme-Linked Immunosorbent Assay
- Female
- Genes, MHC Class I
- Genes, MHC Class II
- Genetic Markers
- HLA-DQ Antigens