Article
Are HLA-DR or TAP genes genetic markers of severity in ulcerative colitis?
Journal of autoimmunity - 1 Dec 1996
Heresbach D, Alizadeh M, Reumaux D, Colombel J F, Delamaire M, Danze P M, Gosselin M, Genetet B, Bretagne J F, Semana G
Abstract excerpt
The pathogeny of ulcerative colitis (UC) is not yet elucidated, but some arguments suggest the implication of genetic factors. Among the candidate genes, those encoding for HLA class II genotypes have been extensively studied in UC; however, discordant data may be imputable to heterogeneity, characterized by immunological markers such as atypical ANCA (p-ANCA), or to inclusion of more or less intractable UC. The...
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