Article
Genome-wide synthetic genetic screening by transposon mutagenesis in Candida albicans.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015
Horton Brooke N, Kumar Anuj
Abstract excerpt
Transposon-based mutagenesis is an effective method for genetic screening on a genome-wide scale, with particular applicability in organisms possessing compact genomes where transforming DNA tends to integrate by homologous recombination. Methods for transposon mutagenesis have been applied with great success in the budding yeast Saccharomyces cerevisiae and in the related pathogenic yeast Candida albicans. In C....
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