Article
Covariation of mutations in the V3 loop of human immunodeficiency virus type 1 envelope protein: an information theoretic analysis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1993
Korber B T, Farber R M, Wolpert D H, Lapedes A S
Abstract excerpt
The V3 loop of the human immunodeficiency virus type 1 (HIV-1) envelope protein is a highly variable region that is both functionally and immunologically important. Using available amino acid sequences from the V3 region, we have used an information theoretic quantity called mutual information, a measure of covariation, to quantify dependence between mutations in the loop. Certain pairs of sites, including...
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