Article
Use of mutual information arrays to predict coevolving sites in the full length HIV gp120 protein for subtypes B and C.
Virologica Sinica - 1 Apr 2011
Wei Bo, Han Na, Liu Hai-zhou, Rayner Anthony, Rayner Simon
Abstract excerpt
It is well established that different sites within a protein evolve at different rates according to their role within the protein; identification of these correlated mutations can aid in tasks such as ab initio protein structure, structure function analysis or sequence alignment. Mutual Information is a standard measure for coevolution between two sites but its application is limited by signal to noise ratio. In...
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