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Article

Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression.

The Journal of biological chemistry - 9 Mar 2012

Dey Siddharth S, Xue Yuhua, Joachimiak Marcin P, Friedland Gregory D, Burnett John C, Zhou Qiang, Arkin Adam P, Schaffer David V

Abstract excerpt

Viral genomes are continually subjected to mutations, and functionally deleterious ones can be rescued by reversion or additional mutations that restore fitness. The error prone nature of HIV-1 replication has resulted in highly diverse viral sequences, and it is not clear how viral proteins such as Tat, which plays a critical role in viral gene expression and replication, retain their complex functions. Although...

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Share to Gene Expression Regulation, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22253435
DOI: 10.1074/jbc.M111.302653
PMCID: PMC3318752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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