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Article

Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002

Fewell Sheara W, Pipas James M, Brodsky Jeffrey L

Abstract excerpt

Simian virus 40 large T antigen contains an amino terminal J domain that catalyzes T antigen-mediated viral DNA replication and cellular transformation. To dissect the role of the J domain in these processes, we exploited the genetic tools available only in the yeast Saccharomyces cerevisiae to isolate 14 loss-of-function point mutations in the T antigen J domain. This screen also identified mutations that, when...

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Identifiers

PMID: 11854498
DOI: 10.1073/pnas.042670999
PMCID: PMC122309

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Source receipt: pubmed, retrieved 7 Sept 2026.

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