Mutational analysis of the Prt1 protein subunit of yeast translation initiation factor 3.

doi:10.1128/MCB.15.8.4525

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mutational analysis of the Prt1 protein subunit of yeast translation initiation factor 3.

Molecular and cellular biology - 1 Aug 1995

Evans D R, Rasmussen C, Hanic-Joyce P J, Johnston G C, Singer R A, Barnes C A

Abstract excerpt

The Saccharomyces cerevisiae PRT1 gene product Prt1p is a component of translation initiation factor eIF-3, and mutations in PRT1 inhibit translation initiation. We have investigated structural and functional aspects of Prt1p and its gene. Transcript analysis and deletion of the PRT1 5' end revealed that translation of PRT1 mRNA is probably initiated at the second in-frame ATG in the open reading frame. The amino...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA Mutational Analysis
Eukaryotic Initiation Factor-3
Fungal Proteins
Macromolecular Substances
Molecular Sequence Data
Open Reading Frames

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Chain Initiation, Translational

Peptide Fragments

Peptide Initiation Factors

Polymorphism, Genetic

Prokaryotic Initiation Factor-3

Protein Synthesis Inhibitors

RNA Precursors

RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7623843
DOI: 10.1128/MCB.15.8.4525
PMCID: PMC230692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7623843-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the Prt1 protein subunit of yeast translation initiation factor 3.PMID 7623843Read ↗

Yeast prt1 mutations alter heat-shock gene expression through transcript fragmentation.Semantic proximity Read ↗

Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeast.Semantic proximity Read ↗

Functions of eIF3 downstream of 48S assembly impact AUG recognition and GCN4 translational control.Semantic proximity Read ↗

An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA.Semantic proximity Read ↗

Mutations in a peptidylprolyl-cis/trans-isomerase gene lead to a defect in 3'-end formation of a pre-mRNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

Nip1p associates with 40 S ribosomes and the Prt1p subunit of eukaryotic initiation factor 3 and is required for efficient translation initiation.Semantic proximity Read ↗

A mutation in a methionine tRNA gene suppresses the prp2-1 Ts mutation and causes a pre-mRNA splicing defect in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling.Semantic proximity Read ↗

Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly.Semantic proximity Read ↗

A novel gene, spp91-1, suppresses the splicing defect and the pre-mRNA nuclear export in the prp9-1 mutant.Semantic proximity Read ↗

Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.