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Article

Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study.

Carcinogenesis - 1 Oct 2002

Perera Frederica P, Mooney LaVerne A, Stampfer Meir, Phillips David H, Bell Douglas A, Rundle Andrew, Cho Stan, Tsai Wei-Yann, Ma Jing, Blackwood Anne, Tang Deliang

Abstract excerpt

DNA damage from polycyclic aromatic hydrocarbons (PAH) and other aromatic/hydrophobic compounds has been implicated in case-control studies as a risk factor for lung cancer, as have common polymorphisms in the glutathione S-transferase (GST) genes involved in carcinogen detoxification. However, their joint effects have not been evaluated in prospective studies, leaving open questions about predictive value of...

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Source

Identifiers

PMID: 12376472
DOI: 10.1093/carcin/23.10.1641

Genes

GSTP1
GSTM1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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