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Article

Protein kinase Cepsilon is oncogenic in colon epithelial cells by interaction with the ras signal transduction pathway.

Oncogene - 25 Jun 1998

Perletti G P, Concari P, Brusaferri S, Marras E, Piccinini F, Tashjian A H

Abstract excerpt

We have shown previously that overexpression of the epsilon isoform of protein kinase C (PKCepsilon) in rat colonic epithelial cells causes malignant transformation, possibly by interacting with the ras signal transduction pathway (Oncogene 12: 847, 1996). We have now performed experiments to exa...

Topics

Animals
Cell Division
Cell Line
Cell Line, Transformed
Cell Transformation, Neoplastic
Colon
Epithelial Cells
Genes, ras
Isoenzymes
Mutation
Phosphorylation
Protein Kinase C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase C-epsilon

Proto-Oncogene Proteins c-raf

Signal Transduction

ras Proteins

Source

Identifiers

PMID: 9681835
DOI: 10.1038/sj.onc.1201871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9681835-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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