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Article

The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.

Blood - 15 Apr 2002

He Yiping, Wertheim Jason A, Xu Lanwei, Miller Juli P, Karnell Fredrick G, Choi John K, Ren Ruibao, Pear Warren S

Abstract excerpt

The bcr/abl fusion in chronic myelogenous leukemia (CML) creates a chimeric tyrosine kinase with dramatically different properties than intact c-abl. In P210 bcr/abl, the bcr portion includes a coiled-coil oligomerization domain (amino acids 1-63) and a grb2-binding site at tyrosine 177 (Tyr177) that are critical for fibroblast transformation, but give variable results in other cell lines. To investigate the role...

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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Share to Neoplasms, Experimental

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Source

Identifiers

PMID: 11929787
DOI: 10.1182/blood.v99.8.2957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.PMID 11929787Read ↗

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