Article
Recurrent rearrangements of FOS and FOSB define osteoblastoma.
Nature communications - 1 Jun 2018
Fittall Matthew W, Mifsud William, Pillay Nischalan, Ye Hongtao, Strobl Anna-Christina, Verfaillie Annelien, Demeulemeester Jonas, Zhang Lei, Berisha Fitim, Tarabichi Maxime, Young Matthew D, Miranda Elena, Tarpey Patrick S, Tirabosco Roberto, Amary Fernanda, Grigoriadis Agamemnon E, Stratton Michael R, Van Loo Peter, Antonescu Cristina R, Campbell Peter J, Flanagan Adrienne M, Behjati Sam
Abstract excerpt
The transcription factor FOS has long been implicated in the pathogenesis of bone tumours, following the discovery that the viral homologue, v-fos, caused osteosarcoma in laboratory mice. However, mutations of FOS have not been found in human bone-forming tumours. Here, we report recurrent rearrangement of FOS and its paralogue, FOSB, in the most common benign tumours of bone, osteoblastoma and osteoid osteoma....
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