Article
Possible role of activated ras genes in human esophageal carcinogenesis.
International journal of cancer - 30 Jul 1993
Galiana C, Fusco A, Martel N, Nishihira T, Hirohashi S, Yamasaki H
Abstract excerpt
Activation by point mutation of the H-, K- and N-ras genes is found in many tumors. However, no such mutation has yet been found in human esophageal carcinomas from various parts of the world. We have confirmed the absence of mutation at codons 12, 13 and 61 of K- and N-ras and at codons 12 and 61 of H-ras in 25 primary tumors obtained in France. In contrast, among 7 human esophageal carcinoma cell lines (TE1,...
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