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Article

Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae.

The Journal of cell biology - 1 Aug 1993

Holtzman D A, Yang S, Drubin D G

Abstract excerpt

Abplp is a yeast cortical actin-binding protein that contains an SH3 domain similar to those found in signal transduction proteins that function at the membrane/cytoskeleton interface. Although no detectable phenotypes are associated with a disruption allele of ABP1, mutations that create a requirement for this protein have now been isolated in the previously identified gene SAC6 and in two new genes, SLA1 and...

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Source

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Identifiers

PMID: 8335689
DOI: 10.1083/jcb.122.3.635
PMCID: PMC2119656

Genes

SLA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae.PMID 8335689Read ↗

Mapping actin surfaces required for functional interactions in vivo.Semantic proximity Read ↗

Sla1p is a functionally modular component of the yeast cortical actin cytoskeleton required for correct localization of both Rho1p-GTPase and Sla2p, a protein with talin homology.Semantic proximity Read ↗

An interaction between Sla1p and Sla2p plays a role in regulating actin dynamics and endocytosis in budding yeast.Semantic proximity Read ↗

Structural and functional dissection of the Abp1 ADFH actin-binding domain reveals versatile in vivo adapter functions.Semantic proximity Read ↗

SCP1 encodes an actin-bundling protein in yeast.Semantic proximity Read ↗

Sla2p is associated with the yeast cortical actin cytoskeleton via redundant localization signals.Semantic proximity Read ↗

Bsp1p/Ypr171p is an adapter that directly links some synaptojanin family members to the cortical actin cytoskeleton in yeast.Semantic proximity Read ↗

Suppressor analysis of fimbrin (Sac6p) overexpression in yeast.Semantic proximity Read ↗

Mutations that enhance the cap2 null mutant phenotype in Saccharomyces cerevisiae affect the actin cytoskeleton, morphogenesis and pattern of growth.Semantic proximity Read ↗

Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast.Semantic proximity Read ↗

Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae.Semantic proximity Read ↗

Actin mutations that show suppression with fimbrin mutations identify a likely fimbrin-binding site on actin.Semantic proximity Read ↗

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