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Increased Cytosine DNA-Methyltransferase Activity During Colon Cancer Progression

4 Aug 1993

Abstract excerpt

BACKGROUND: Molecular changes during progressive stages of colon cancer and other human tumors commonly involve altered regulation of DNA methylation. These changes include overall genomic hypomethylation, regional hypermethylation, and increased levels of messenger RNA (mRNA) for cytosine DNA-methyltransferase (DNA-MTase), the enzyme that catalyzes DNA methylation at CpG (cytosine-phospho-guanine) sites. This...

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Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer
Share to Genomic variations and chromosomal abnormalities

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PMID: 8331684
DOI: 10.1093/jnci/85.15.1235

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