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Article

A specific CpG methylation pattern of theMGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

1 Feb 1999

Abstract excerpt

The enzyme O6-methylguanine-DNA methyltransferase (MGMT) protects cells from the cytotoxic and mutagenic effects of alkylating agents. Approximately 20% of tumor cell lines lack MGMT activity and are highly sensitive to alkylating agents. In established cancer cell lines, MGMT expression appears to be correlated with methylation of residues in both the promoter and the body of the gene. The effect of methylation...

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PMID: 10078936
DOI: 10.1002/(sici)1098-2744(199902)24:2<90::aid-mc3>3.0.co;2-b

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