Article
Essential similarities between spontaneous and MeIQx-promoted aberrant crypt foci in the F344 rat colon.
Cancer letters - 30 Oct 2001
Tanakamaru Z, Mori I, Nishikawa A, Furukawa F, Takahashi M, Mori H
Abstract excerpt
Aberrant crypt foci (ACFs) in the Fischer 344 (F344) rat colon, of control or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-treated groups, were compared morphologically, immunohistochemically, and at the molecular biological level in order to elucidate their biological characteristics. Male 3-week-old rats were fed a diet supplemented with or without MeIQx at doses of 100 ppm or less for 16 weeks. The...
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