Essential similarities between spontaneous and MeIQx-promoted aberrant crypt foci in the F344 rat colon.

doi:10.1016/s0304-3835(01)00636-x

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Article

Essential similarities between spontaneous and MeIQx-promoted aberrant crypt foci in the F344 rat colon.

Cancer letters - 30 Oct 2001

Tanakamaru Z, Mori I, Nishikawa A, Furukawa F, Takahashi M, Mori H

Abstract excerpt

Aberrant crypt foci (ACFs) in the Fischer 344 (F344) rat colon, of control or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-treated groups, were compared morphologically, immunohistochemically, and at the molecular biological level in order to elucidate their biological characteristics. Male 3-week-old rats were fed a diet supplemented with or without MeIQx at doses of 100 ppm or less for 16 weeks. The...

Topics

Animals
Carcinogens
Colonic Neoplasms
Genes, ras
Male
Mutagens
Mutation
Precancerous Conditions
Proliferating Cell Nuclear Antigen
Quinoxalines
Rats
Rats, Inbred F344
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 11566489
DOI: 10.1016/s0304-3835(01)00636-x

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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