Article
p53 mutation in fresh lymphocytes, B-lymphoblastoid cell lines and their transformed cell lines originating from Bloom syndrome patients.
Cancer genetics and cytogenetics - 1 Jul 1993
Shiraishi Y
Abstract excerpt
To elucidate the molecular basis for malignant and premalignant states in Bloom syndrome (BS), p53 mutations were analyzed using Southern blot analysis and DNA sequencing of exons 5-9. p53 point mutations with and without loss of heterozygosity on 17p were detected in malignantly transformed BS cell lines carrying malignant lymphoma (ML) and stomach cancer (STC) antigens on the cell surface. However, p53...
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