Article
p53 splice acceptor site mutation and increased HsRAD51 protein expression in Bloom's syndrome GM1492 fibroblasts.
Gene - 4 Apr 2000
Magnusson K P, Sandström M, Ståhlberg M, Larsson M, Flygare J, Hellgren D, Wiman K G, Ljungquist S
Abstract excerpt
GM1492 human diploid skin fibroblasts derived from a patient with Bloom's syndrome (BS), lack detectable p53 mRNA and protein as shown by Northern and Western blotting, and express an increased RecA-like activity. Here we demonstrate that the p53 gene is grossly intact in GM1492 cells according to Southern blotting. DNA sequencing did not reveal any mutations in the promoter region of p53. A highly sensitive...
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