Article
Defective HLA class II expression in monocytes of type 1 diabetic patients. The Childhood Diabetes in Finland Study Group.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 May 1993
Parkkonen P, Hyöty H, Huupponen T, Leinikki P, Tuomilehto-Wolf E, Knip M
Abstract excerpt
Activation of T-helper cells is modulated by the intensity of HLA class II expression on antigen-presenting cells. We evaluated whether any abnormalities could be found in the expression of HLA-DR and -DQ molecules on monocytes in type 1 diabetic subjects. DR and DQ molecules were induced by human recombinant interferon-gamma on cultured peripheral blood monocytes obtained from children with type 1 diabetes (N =...
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