Article
Crosstalk between site-specific modifications on p53 and histone H3.
Oncogene - 6 Mar 2008
Warnock L J, Adamson R, Lynch C J, Milner J
Abstract excerpt
Previously, we have observed a link between p53 expression and histone H3 post-translational modifications. Here, we ask if specific post-translational modifications of p53 impact upon histone H3 modifications in a selective manner. We have also screened for internal co-operative effects within the repertoire of p53 modifications. Exogenous p53 constructs were expressed in HCT116 p53-/- cells. Four mutant p53...
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