Article
mnd2: a new mouse model of inherited motor neuron disease.
Genomics - 1 Jun 1993
Jones J M, Albin R L, Feldman E L, Simin K, Schuster T G, Dunnick W A, Collins J T, Chrisp C E, Taylor B A, Meisler M H
Abstract excerpt
The autosomal recessive mutation mnd2 results in early onset motor neuron disease with rapidly progressive paralysis, severe muscle wasting, regression of thymus and spleen, and death before 40 days of age. mnd2 has been mapped to mouse chromosome 6 with the gene order: centromere-Tcrb-Ly-2-Sftp-...
Topics
- Animals
- Chromosome Mapping
- Disease Models, Animal
- Electrophysiology
- Heterozygote
- Humans
- Intermediate Filaments
- Lymphoid Tissue
- Mice
- Mice, Inbred C57BL
- Motor Neuron Disease
- Motor Neurons