Article
Neuromuscular ataxia: a new spontaneous mutation in the mouse.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2000
Ward-Bailey P F, Wood B, Johnson K R, Bronson R T, Donahue L R, Davisson M T
Abstract excerpt
Neuromuscular ataxia, nma, is a new autosomal recessive mutation that arose spontaneously in CBA/J inbred mice at The Jackson Laboratory. The mutation, now maintained on the B6C3FeF(1) hybrid background, when homozygous, causes small size, uncoordinated gait, dysmetria, dystonia, general weakness, and death shortly after weaning. No biochemical or morphological abnormalities have been detected. We used an...
Topics
- Animals
- Ataxia
- Blotting, Northern
- Blotting, Southern
- Chromosome Mapping
- Chromosomes
- DNA
- Heterozygote
- Humans
- Mice
- Mice, Inbred CBA
- Mutation
- Neuromuscular Diseases
- Phenotype