Article
Progressive loss of striatal neurons causes motor dysfunction in MND2 mutant mice and is not prevented by Bcl-2.
Experimental neurology - 1 May 2002
Rathke-Hartlieb Silvia, Schlomann Uwe, Heimann Peter, Meisler Miriam H, Jockusch Harald, Bartsch Jörg W
Abstract excerpt
The mouse mutant "motoneuron disease 2" (MND2, mnd2 on Chr 6) was originally characterized as a spinal muscular atrophy (SMA) because degenerating motoneurons were observed in late stages of the disease. MND2 mutants exhibit a progressive phenotype with neurological symptoms that begin at postnatal day (dP) 20 and include involuntary movements, abnormal postures, akinesis, and death between dP 30 and 40....
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