Lack of effect of proguanil on the pharmacokinetics of dapsone in healthy volunteers.

Abstract excerpt

The multiple-dose kinetics of dapsone (DDS) and its principal metabolite monoacetyldapsone (MADDS) were determined in 6 healthy volunteers after daily administration of low-dose dapsone (10 mg). Comparison with a previous study involving the same volunteers on a daily regimen of proguanil (200 mg) plus dapsone (10 mg) revealed no statistically significant differences in the maximum plasma concentrations, area...

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