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Article

Demonstration of protection in mice from a lethal challenge of three M serotypes of Streptococcus pyogenes using an M-negative vaccine.

Vaccine - 1 Jan 1993

Chappell J D, Stuart J G

Abstract excerpt

Mice were vaccinated with a temperature-sensitive, M-negative mutant (JC3) of Streptococcus pyogenes. This vaccine was found to offer protection from a lethal challenge of homologous M-negative and type 28 M-positive strains of S. pyogenes as well as heterologous M3 and M18 strains. Using an immunoblot method, hyperimmune serum from mice vaccinated with JC3 was found to contain moderate to high titres of antibody...

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Identifiers

PMID: 8322487
DOI: 10.1016/0264-410x(93)90310-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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