Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preclinical safety and immunogenicity of Streptococcus pyogenes (Strep A) peptide vaccines

8 Jan 2021

Abstract excerpt

Abstract We have developed two candidate vaccines to protect against multiple strains of Strep A infections. The candidates are combinatorial synthetic peptide vaccines composed of a M protein epitope (J8 or p*17) and a non-M protein epitope (K4S2). To enhance immunogenicity, each peptide is conjugated to the carrier protein CRM197 (CRM) and formulated with aluminium hydroxide adjuvant Alhydrogel (Alum) to make...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Resistance in Staphylococcus
Share to Inflammasome and immune disorders
Share to Streptococcal Infections and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33420258
DOI: 10.1038/s41598-020-80508-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preclinical safety and immunogenicity of Streptococcus pyogenes (Strep A) peptide vaccinesPMID 33420258Read ↗

Immunogenicity in mice and non-human primates of the Group A Streptococcal J8 peptide vaccine candidate conjugated to CRM197Semantic proximity Read ↗

Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with group A streptococciSemantic proximity Read ↗

Combinatorial Synthetic Peptide Vaccine Strategy Protects against Hypervirulent CovR/S Mutant StreptococciSemantic proximity Read ↗

Polymeric epitope-based vaccine induces protective immunity against group A StreptococcusSemantic proximity Read ↗

Molecular biology of Group A Streptococcus and its implications in vaccine strategies.Semantic proximity Read ↗

Enhancing Vaccine Efficacy by Engineering a Complex Synthetic Peptide To Become a Super Immunogen.Semantic proximity Read ↗

Unveiling the Group A Streptococcus Vaccine-Based L-Rhamnose from Backbone of Group A Carbohydrate: Current Insight Against Acute Rheumatic Fever to Reduce the Global Burden of Rheumatic Heart DiseaseSemantic proximity Read ↗

A Lipid Core Peptide Construct Containing a Conserved Region Determinant of the Group A Streptococcal M Protein Elicits Heterologous Opsonic AntibodiesSemantic proximity Read ↗

StreptInCor: A Candidate Vaccine Epitope against S. pyogenes Infections Induces Protection in Outbred MiceSemantic proximity Read ↗

Will there ever be a universal<i>Staphylococcus aureus</i>vaccine?Semantic proximity Read ↗

Anti-Group A Streptococcal Vaccine EpitopeSemantic proximity Read ↗

Inhibition of Bacterial Superantigens by Peptides and AntibodiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.